PROPOFOL

‘DIPRIVAN’

1) Action

• Ultra short acting anaesthetic agent

2) Mechanism

3) Indications

• Induction & maintenance of anaesthesia

4) Effects on organs—side effects

• Predictable depressant action on respiration & circulation

5) Toxic effects/ precautions with administration

• Has no analgesic properties

• 14% patients show excitation

6) Contraindications

7) Reversal, antagonism or antidote

8) Loading dose, maintenance dose, frequency & method of administration

• Ampoules 10 mg/ml: 20 ml

• 150mg/ 70Kg

• Cessation of action with 8 minutes

9) Drug’s metabolism—Drug’s excretion—Half life (pharmacokinetics)

• Short duration of action due liver metabolism

10) Important drug interactions