HALOTHANE

“FLUOTHANE”

1) Action

• General anaesthetic

2) Mechanism

3) Indications

• Induction & maintenance of general anaesthesia

4) Effects on organs—side effects

• Decreases MAP in direct proportion to alveolar concentration due to reduction in SVR

• Cardiac depression; bradycardia

• Cardiac irritability

5) Toxic effects/ precautions with administration

• Rarely causes liver disease [‘halothane hepatitis’]

• Due to cardiac irritation, avoid when administering adrenaline

6) Contraindications

• Hepatic necrosis

7) Reversal, antagonism or antidote

• Reversal by ventilation with pure oxygen

8) Loading dose, maintenance dose, frequency & method of administration

9) Drug’s metabolism—Drug’s excretion—Half life (pharmacokinetics)

• Potent anaesthetic; MAC 0.75%

10) Important drug interactions