ENFLURANE

“ETHRANE”

1) Action

• General anaesthetic

2) Mechanism

3) Indications

• Induction & maintenance of general anaesthesia

4) Effects on organs—side effects

• Decreases MAP in direct proportion to alveolar concentration due to reduction in CO, minimal effect on SVR

• May increase heart rate

• Very depressant on myocardium

• Decreases metabolic rate of brain

• Increases cerebral blood flow

• Secretions may be increased

5) Toxic effects/ precautions with administration

• May be associated with hyperglycaemia

6) Contraindications

• Hepatic necrosis

7) Reversal, antagonism or antidote

• Reversal by ventilation with pure oxygen

8) Loading dose, maintenance dose, frequency & method of administration

• For induction: start at 0.5% at increase by increments of 5% until surgical anaesthesia achieved

• Maintenance at 0.5-2%

• Recovery: reduce to 0.5% near end of surgical procedure

9) Drug’s metabolism—Drug’s excretion—Half life (pharmacokinetics)

• MAC (minimum alveolar concentration): 1.68